Entocort®(budesonide) CR 3 mg Capsules

Crohn’s Disease:

• Induction of remission in patients with mild to moderate active Crohn’s disease affecting the ileum and/or the ascending colon¹

Microscopic colitis:

• Induction of remission in patients with active microscopic colitis¹
• Maintenance of remission in patients with microscopic colitis¹.

Budesonide CR 3 mg Capsules are a hard gelatin capsule containing budesonide 3mg in the form of granules.²

The granules have an outer enteric coating and an inner ethylcellulose matrix containing budesonide, providing both a PH-dependent and time-dependent release.²

pH-dependent release^3-4:

• Each granule has a pH-sensitive enteric coating.
• The enteric coating begins to dissolve when the granules enter the duodenum (pH>5.5), exposing the ethylcellulose matrix.

Time-dependent release^4-8:

• Budesonide is embedded within the ethylcellulose matrix.
• The ethylcellulose matrix gradually releases budesonide, delivering it throughout the ileum, all the way to the descending colon.^*

The ethylcellulose delivery mechanism helps to concentrate the absorption and anti-inflammatory action of budesonide in the sites most commonly affected by Crohn’s disease. ^2,5,6

^{*Budesonide CR 3 mg Capsules are indicated for the induction of remission in adults with mild to moderate active Crohn’s disease affecting the ileum and/or ascending colon.1}